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secobarbital will decrease the extent or effect of etoposide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.secobarbital will minimize the level or effect of levonorgestrel intrauterine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Caution must be exercised when Seconal Sodium (s